Life Sciences - Research Group of Sebastian Thallmair

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Open Projects and Job Offers

We offer exciting projects and are looking forward to working together with creative and highly motivated co-workers at different levels of expertise. Our research projects cover an interdisciplinary range of topics connecting the research fields of biophysics, medicinal chemistry, and biology. Primarily, we use computational modeling of biological systems at various time and length scales.

Postdoc Positions

Currently, there are no open postdoc positions.

If you are interested in a postdoc stay in our group, please contact Dr. Sebastian Thallmair. We will support you during writing your own grant proposal to secure funding for your postdoc stay in the Thallmair group. Possible options for funding are Marie Skłodowska-Curie Actions Individual Fellowships, a Humboldt fellowship, or an EMBO fellowship.

PhD Positions

Currently, there are no open PhD positions.

If you are interested in doing your PhD in our group, please contact Dr. Sebastian Thallmair. We will support you during writing your own grant proposal to secure funding for your PhD in the Thallmair group. Possible options for funding are provided by the German Academic Excange Service (DAAD) or the Boehringer-Ingelheim Foundation.

Master thesis, Bachelor thesis, and research internships

We offer opportunities for Master and Bachelor theses in the field of molecular dynamics simulations of biomolecular systems and computational drug design. We are also happy to host Erasmus+ students in the Thallmair group.

Currently, we offer a Master thesis in the field of light-switchable protein ligands. These protein ligands contain a molecular switch, which can be switched between two different conformations by means of light. G-Protein coupled receptors (GPCRs) are an interesting class of target proteins, for which so far only a few light-switchable ligands are exist. We will use molecular dynamics simulations to investigate the different binding behavior of both conformers with the GPCR and to compare it to conventional ligands.

For Bachelor theses, we offer projects to investigate a selected ligand and its binding to a target protein by means of coarse-grained molecular dynamics simulations. First, a model for the ligand has to be developed. Then, its interaction with the protein can be simulated. Interesting target proteins are for instance kinases, whose inhibition plays an important role in cancer therapy.

Please contact Dr. Sebastian Thallmair if you are interested to hear more details about possible Bachelor or Master projects. We are looking forward to hearing from you!